Lipopolysaccharide (LPS) is a bacterial endotoxin, and a major constituent of the cell walls of gram-negative bacteria. During gram-negative bacteremia or endotoxemia, LPS is theprincipal pathophysiological mediator by which bacteria can cause hypotension, organ failure, disseminated intravascular coagulation, and fatal shock in mammalian hosts. The removal of these endotoxins is highly necessary for downstream processes.The ToxinEraserTMEndotoxin Removal Resinutilizes immobilized polymixin B to bind andremove pyrogens from solution. Thepolymixins are a family of antibiotics that contain a cationic cyclopeptide with a fatty acid chain. Polymixin B neutralizes thebiologicalactivity of endotoxins by binding to the lipid A portion of bacterial lipopolysaccharide.